Production of gamma-aminobutyric acid from lactic acid bacteria: A systematic review

Y Cui, K Miao, S Niyaphorn, X Qu - International Journal of Molecular …, 2020 - mdpi.com
Gamma-aminobutyric acid (GABA) is widely distributed in nature and considered a potent
bioactive compound with numerous and important physiological functions, such as anti …

Glutamate decarboxylase from lactic acid bacteria—A key enzyme in GABA synthesis

IBA Yogeswara, S Maneerat, D Haltrich - Microorganisms, 2020 - mdpi.com
Glutamate decarboxylase (l-glutamate-1-carboxylase, GAD; EC 4.1. 1.15) is a pyridoxal-5'-
phosphate-dependent enzyme that catalyzes the irreversible α-decarboxylation of l-glutamic …

GABA production and structure of gadB/gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota

RA Yunes, EU Poluektova, MS Dyachkova, KM Klimina… - Anaerobe, 2016 - Elsevier
Gamma-amino butyric acid (GABA) is an active biogenic substance synthesized in plants,
fungi, vertebrate animals and bacteria. Lactic acid bacteria are considered the main …

Strategies for improvement of gamma-aminobutyric acid (GABA) biosynthesis via lactic acid bacteria (LAB) fermentation

S Pannerchelvan, L Rios-Solis, FWF Wong… - Food & Function, 2023 - pubs.rsc.org
Gamma-aminobutyric acid (GABA) is a non-protein amino acid widely distributed in nature
and extensively explored for its numerous physiological functions and effects on metabolic …

High γ-aminobutyric acid production from lactic acid bacteria: Emphasis on Lactobacillus brevis as a functional dairy starter

Q Wu, NP Shah - Critical Reviews in Food Science and Nutrition, 2017 - Taylor & Francis
ABSTRACT γ-Aminobutyric acid (GABA) and GABA-rich foods have shown anti-
hypertensive and anti-depressant activities as the major functions in humans and animals …

Biotechnological advances and perspectives of gamma-aminobutyric acid production

N Xu, L Wei, J Liu - World Journal of Microbiology and Biotechnology, 2017 - Springer
Gamma-aminobutyric acid (GABA) is a four-carbon non-protein amino acid that is widely
distributed among various organisms. Since GABA has several well-known physiological …

Recent advances in microbial production of diamines, aminocarboxylic acids, and diacids as potential platform chemicals and bio-based polyamides monomers

J Son, YJ Sohn, KA Baritugo, SY Jo, HM Song… - Biotechnology …, 2023 - Elsevier
Recently, bio-based manufacturing processes of value-added platform chemicals and
polymers in biorefineries using renewable resources have extensively been developed for …

Common Distribution of gad Operon in Lactobacillus brevis and its GadA Contributes to Efficient GABA Synthesis toward Cytosolic Near-Neutral pH

Q Wu, HM Tun, YS Law, E Khafipour… - Frontiers in …, 2017 - frontiersin.org
Many strains of lactic acid bacteria (LAB) and bifidobacteria have exhibited strain-specific
capacity to produce γ-aminobutyric acid (GABA) via their glutamic acid decarboxylase (GAD) …

Integrating Enzyme Evolution and Metabolic Engineering to Improve the Productivity of Γ-Aminobutyric Acid by Whole-Cell Biosynthesis in Escherichia Coli

X Yang, X Huo, Y Tang, M Zhao, Y Tao… - Journal of Agricultural …, 2023 - ACS Publications
γ-Aminobutyric acid (GABA) is used widely in various fields, such as agriculture, food,
pharmaceuticals, and biobased chemicals. Based on glutamate decarboxylase (GadBM4) …

Expanding the active pH range of Escherichia coli glutamate decarboxylase by breaking the cooperativeness

NAT Ho, CY Hou, WH Kim, TJ Kang - Journal of bioscience and …, 2013 - Elsevier
Bacterial glutamate decarboxylase (GAD) transforms glutamate into γ-aminobutyric acid
(GABA) with the consumption of a proton. The enzyme is active under acidic environments …