Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury

QM Chen - Free Radical Biology and Medicine, 2022 - Elsevier
Myocardial infarction is the most common form of acute coronary syndrome. Blockage of a
coronary artery due to blood clotting leads to ischemia and subsequent cell death in the form …

The role of flavonoids as a cardioprotective strategy against doxorubicin-induced cardiotoxicity: a review

RA Syahputra, U Harahap, A Dalimunthe, MP Nasution… - Molecules, 2022 - mdpi.com
Doxorubicin is a widely used and promising anticancer drug; however, a severe dose-
dependent cardiotoxicity hampers its therapeutic value. Doxorubicin may cause acute and …

Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson's Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut …

L Wang, Z Zhao, L Zhao, Y Zhao, G Yang… - Journal of Agricultural …, 2022 - ACS Publications
This study aimed to evaluate the attenuating effect of Lactobacillus plantarum DP189 on α-
synuclein (α-SYN) aggregates in the substantia nigra (SN) of Parkinson's disease (PD) mice …

Nrf2 signaling pathway in chemoprotection and doxorubicin resistance: potential application in drug discovery

S Mirzaei, A Zarrabi, F Hashemi, A Zabolian, H Saleki… - Antioxidants, 2021 - mdpi.com
Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …

Nrf2: a dark horse in doxorubicin-induced cardiotoxicity

X Zhao, Z Tian, M Sun, D Dong - Cell death discovery, 2023 - nature.com
Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment.
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …

Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN

R Ji, F Jia, X Chen, Z Wang, W Jin, J Yang - Archives of Biochemistry and …, 2022 - Elsevier
In the past few years, emerging evidence established persistent oxidative stress to be a key
player in the pathogenesis of polycystic ovary syndrome (PCOS). Particularly, it damages …

Dexrazoxane ameliorates doxorubicin-induced cardiotoxicity by inhibiting both apoptosis and necroptosis in cardiomyocytes

X Yu, Y Ruan, X Huang, L Dou, M Lan, J Cui… - Biochemical and …, 2020 - Elsevier
Doxorubicin, as a first line chemotherapeutic agent, its usage is limited owing to
cardiotoxicity. Necroptosis is a new form of programmed cell death, and recent …

Current status of obesity: Protective role of catechins

T Basu, A Selman, AP Reddy, PH Reddy - Antioxidants, 2023 - mdpi.com
Obesity is a growing health concern in today's society. Current estimates indicate that
obesity occurs in both adults and young people. Recent research also found that the …

[HTML][HTML] Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway

M Ding, R Shi, F Fu, M Li, D De, Y Du, Z Li - Journal of Advanced Research, 2023 - Elsevier
Introduction The anti-cancer medication doxorubicin (Dox) is largely restricted in clinical
usage due to its significant cardiotoxicity. The only medication approved by the FDA for Dox …

Effects of chitosan oligosaccharides (COS) and FMT from COS-dosed mice on intestinal barrier function and cell apoptosis

K Na, J Wei, L Zhang, Y Fang, X Li, S Lu, X Guo - Carbohydrate Polymers, 2022 - Elsevier
Chitosan oligosaccharides (COS) show the potential to support the intestinal health, but the
mechanism and role of COS-derived intestinal microbiota are unknown. We explored the …