Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease
Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …
worldwide, has brought enormous challenge to the society. Due to its extremely complex …
Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Design, synthesis, antioxidant and anticholinesterase activities of novel isonicotinic hydrazide-hydrazone derivatives
The design and synthesis of hydrazone derivatives are increasing in popularity day by day
due to the significant biological activities of this scaffold. In the present study, twelve novel …
due to the significant biological activities of this scaffold. In the present study, twelve novel …
Anticholinesterase activities of novel indole-based hydrazide-hydrazone derivatives: design, synthesis, biological evaluation, molecular docking study and in silico …
ED Coşar, ED Dincel, S Demiray, E Sucularlı… - Journal of Molecular …, 2022 - Elsevier
A series of novel indole-based hydrazide-hydrazone derivatives were synthesized and
evaluated for their AChE and BuChE inhibitory activities. The structural elucidations of the …
evaluated for their AChE and BuChE inhibitory activities. The structural elucidations of the …
The design of novel 4, 6-dimethoxyindole based hydrazide-hydrazones: Molecular modeling, synthesis and anticholinesterase activity
Abstract Biologically important hydrazide-hydrazone (–(C= O) NHN= CH) functionality was
located at two different positions on 4, 6-dimethoxyindole moiety and novel compounds 11a …
located at two different positions on 4, 6-dimethoxyindole moiety and novel compounds 11a …
Designing heterocyclic chalcones, benzoyl/sulfonyl hydrazones: An insight into their biological activities and molecular docking study
The aim of this study is to investigate the antioxidant, anticholinesterase and the
antiproliferative activities of some chalcones, benzoyl and sulfonyl hydrazones. The …
antiproliferative activities of some chalcones, benzoyl and sulfonyl hydrazones. The …
Homoleptic metal complexes derived from hydrazones as ligand; synthesis, cytotoxic activity, photoluminescence properties and ADMET studies
In the present work, N'-(2‑hydroxy-5-nitrobenzylidene) thiophene-2-carbohydrazide (L) and
its Cu (II), Ni (II), Co (II), and Fe (II) complexes have been prepared. Their chemical …
its Cu (II), Ni (II), Co (II), and Fe (II) complexes have been prepared. Their chemical …
Hydrazones of 4-(trifluoromethyl) benzohydrazide as new inhibitors of acetyl-and butyrylcholinesterase
M Krátký, K Svrčková, QA Vu, Š Štěpánková, J Vinšová - Molecules, 2021 - mdpi.com
Based on the broad spectrum of biological activity of hydrazide–hydrazones, trifluoromethyl
compounds, and clinical usage of cholinesterase inhibitors, we investigated hydrazones …
compounds, and clinical usage of cholinesterase inhibitors, we investigated hydrazones …
Design, synthesis, biological activity evaluation and in silico studies of new nicotinohydrazide derivatives as multi-targeted inhibitors for Alzheimer's disease
A new series of 6‑chloro-N'-(substituted benzylidene) nicotinohydrazide were synthesized
via condensation reactions between the corresponding hydrazides and aldehydes. All …
via condensation reactions between the corresponding hydrazides and aldehydes. All …
Synthesis, biological evaluation, theoretical investigations, docking study and ADME parameters of some 1, 4-bisphenylhydrazone derivatives as potent antioxidant …
I Amine Khodja, H Boulebd - Molecular Diversity, 2021 - Springer
Abstract Five 1, 4-bisphenylhydrazone derivatives (1–5) were successfully synthesized and
evaluated for their antioxidant and acetylcholinesterase inhibitory activities. The antioxidant …
evaluated for their antioxidant and acetylcholinesterase inhibitory activities. The antioxidant …