Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

BackgroundThe nosology of the psychosis high-risk state is controversial. Traditionally
conceived as an 'at risk'state for the development of psychotic disorders, it is also …

Importance Social and occupational impairments contribute to the burden of psychosis and
depression. There is a need for risk stratification tools to inform personalized functional …

The aim of this guidance paper of the European Psychiatric Association is to provide
evidence-based recommendations on the early detection of a clinical high risk (CHR) for …

Background: The current diagnostic system for subjects at enhanced clinical risk of
psychosis allows concurrent comorbid diagnoses of anxiety and depressive disorders. Their …

Intervention at the earliest illness stage, in ultra or clinical high-risk individuals, or indicated
prevention, currently represents the most promising strategy to ameliorate, delay or prevent …

Adolescence is characterized by significant changes in several domains, including brain
structure and function, puberty, and social and environmental factors. Some of these …

Negative symptoms are present in the psychosis prodrome. However, the extent to which
these symptoms are present prior to the onset of the first episode of psychosis remains …

Importance A major public health concern associated with schizophrenia and psychotic
disorders is the long-term disability that involves impaired cognition, lack of social support …

Objective: As part of the second phase of the North American Prodrome Longitudinal Study
(NAPLS-2), Cannon and colleagues report, concurrently with the present article, on a risk …