Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes
MJ Wolf, A Adili, K Piotrowitz, Z Abdullah, Y Boege… - Cancer cell, 2014 - cell.com
Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and
increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms …
increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms …
Clinical relevance of liver histopathology and different histological classifications of NASH in adults
F Nascimbeni, S Ballestri, MV Machado… - Expert review of …, 2018 - Taylor & Francis
Introduction Nonalcoholic fatty liver disease (NAFLD) encompasses simple steatosis and
steatohepatitis (NASH) with or without fibrosis/cirrhosis and hepatocellular carcinoma …
steatohepatitis (NASH) with or without fibrosis/cirrhosis and hepatocellular carcinoma …
Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans
M Itoh, H Kato, T Suganami, K Konuma, Y Marumoto… - PloS one, 2013 - journals.plos.org
Although macrophages are thought to be crucial for the pathogenesis of chronic
inflammatory diseases, how they are involved in disease progression from simple steatosis …
inflammatory diseases, how they are involved in disease progression from simple steatosis …
The macrophage activation marker sCD 163 is associated with morphological disease stages in patients with non‐alcoholic fatty liver disease
K Kazankov, F Barrera, HJ Møller, C Rosso… - Liver …, 2016 - Wiley Online Library
Abstract Background & Aims Macrophage activation plays a key pathogenic role in
experimental non‐alcoholic fatty liver disease (NAFLD) and contributes to the progression of …
experimental non‐alcoholic fatty liver disease (NAFLD) and contributes to the progression of …
Fat-laden macrophages modulate lobular inflammation in nonalcoholic steatohepatitis (NASH)
Nonalcoholic steatohepatitis (NASH) is characterized by extensive hepatic monocyte
infiltration and monocyte-derived macrophages have an important role in regulating the …
infiltration and monocyte-derived macrophages have an important role in regulating the …
DSS colitis promotes tumorigenesis and fibrogenesis in a choline-deficient high-fat diet-induced NASH mouse model
K Achiwa, M Ishigami, Y Ishizu, T Kuzuya… - Biochemical and …, 2016 - Elsevier
Nonalcoholic steatohepatitis (NASH) patients progress to liver cirrhosis and even
hepatocellular carcinoma (HCC). Several lines of evidence indicate that accumulation of …
hepatocellular carcinoma (HCC). Several lines of evidence indicate that accumulation of …
Macrophage activation marker soluble CD 163 and non‐alcoholic fatty liver disease in morbidly obese patients undergoing bariatric surgery
K Kazankov, J Tordjman, HJ Møller… - Journal of …, 2015 - Wiley Online Library
Abstract Background and Aims Macrophages play an important role in non‐alcoholic fatty
liver disease (NAFLD). Soluble CD 163 (s CD 163) is a specific marker of macrophage …
liver disease (NAFLD). Soluble CD 163 (s CD 163) is a specific marker of macrophage …
Nonalcoholic fatty liver disease and bariatric surgery in adolescents
AX Holterman, J Gurria, S Tanpure… - Seminars in Pediatric …, 2014 - Elsevier
Obesity is a multi-organ system disease with underlying insulin resistance and systemic
chronic inflammation. Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of …
chronic inflammation. Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of …
Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced …
Objective To analyze regulatory microRNA (s) leading to increased TLR2 expression in
livers of high-fat-diet induced metabolic syndrome (HFD-MetS) in rats with non-alcoholic …
livers of high-fat-diet induced metabolic syndrome (HFD-MetS) in rats with non-alcoholic …
[HTML][HTML] Utility of ultrasonography in a mouse model of non-alcoholic steatohepatitis induced by a choline-deficient, high-fat diet and dextran sulfate sodium
F Hayakawa, K Soga, J Fujino, T Ota… - … and Biophysics Reports, 2023 - Elsevier
Background Nonalcoholic steatohepatitis (NASH) is a chronic progressive liver disease that
can progress to cirrhosis and hepatocellular carcinoma. The prevalence of NASH is …
can progress to cirrhosis and hepatocellular carcinoma. The prevalence of NASH is …