Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an
individual's life and on society. Thus, developing more effective therapeutic interventions is …

Schizophrenia is a severe mental illness that affects almost 1% of the population worldwide.
Even though the etiology of schizophrenia is uncertain, it is believed to be a …

G-protein-coupled receptors (GPCRs) play critical roles in regulating brain function. Recent
advances have greatly expanded our understanding of these receptors as complex …

Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of
schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an …

Ketamine, a molecule of many faces, has contributed immeasurably to numerous realms of
clinical practice and scientific inquiry. From anesthesia and analgesia to depression and …

Some humans thrive whereas others resign when exposed to threatening situations
throughout life. Social support has been identified as an important modulator of these …

Astrocytes comprise half of the cells in the central nervous system and play a critical role in
maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

Cellular responses to metabotropic glutamate (mGlu) receptor activation are shaped by
mechanisms of receptor-receptor interaction. mGlu receptor subtypes form homodimers …

Schizophrenia is a common debilitating disease characterized by continuous or relapsing
episodes of psychosis. Although the molecular mechanisms underlying this psychiatric …