Prostate cancer treatment is dominated by strategies to control androgen receptor (AR)
activity. AR has an impact on prostate cancer development through the regulation of not only …

The accurate identification and stratified treatment of clinically significant early-stage
prostate cancer have been ongoing concerns since the outcomes of large international …

The inflammatory microenvironment plays an important role in the pathogenesis and
progression of tumors and may be associated with somatic genomic alterations. We …

Background VHL inactivation is the most established molecular characteristic of clear cell
renal cell carcinoma (ccRCC), with only a few additional genes implicated in development of …

The 2013 discovery of Telomerase reverse transcriptase (TERT) promoter mutations chr5,
1,295,228 C> T (C228T) and 1,295,250 C> T (C250T) in thyroid cancer represents an …

Prostate cancer is the most commonly diagnosed noncutaneous cancer in American men.
TDRD1, a germ cell-specific gene, is erroneously expressed in more than half of prostate …

Various human tissues and cells express phospholipase A1 member A (PLA1A), including
the liver, lung, prostate gland, and immune cells. The enzyme belongs to the pancreatic …

Background Finding the tumor location in the prostate is an essential pathological step for
prostate cancer diagnosis and treatment. The location of the tumor–the laterality–can be …

At least thirteen ETS-domain transcription factors are expressed during embryonic
hematopoietic or vascular development and potentially function in the formation and …

The androgen receptor is a key transcription factor contributing to the development of all
stages of prostate cancer (PCa). In addition, other transcription factors have been associated …