Lipophilic Nucleoside Triphosphate Prodrugs of Anti‐HIV Active Nucleoside Analogs as Potential Antiviral Compounds
X Jia, D Schols, C Meier - Advanced Science, 2023 - Wiley Online Library
Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to
give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate …
give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate …
Antiviral Activity of Lipophilic Nucleoside Tetraphosphate Compounds
X Jia, D Schols, C Meier - Journal of Medicinal Chemistry, 2024 - ACS Publications
We report on the synthesis and characterization of three types of nucleoside tetraphosphate
derivatives 4–9 acting as potential prodrugs of d4T nucleotides:(i) the δ-phosph (on) ate is …
derivatives 4–9 acting as potential prodrugs of d4T nucleotides:(i) the δ-phosph (on) ate is …
Membrane-permeable tenofovir-di-and monophosphate analogues
X Jia, GA Kullik, M Bufano, A Brancale, D Schols… - European Journal of …, 2024 - Elsevier
The development of new antiviral agents such as nucleoside analogues or acyclic
nucleotide analogues (ANPs) and prodrugs thereof is an ongoing task. We report on the …
nucleotide analogues (ANPs) and prodrugs thereof is an ongoing task. We report on the …
Potent Anti‐HIV Activity of Alkyl‐Modified DiPPro‐Nucleotides
X Jia, D Schols, C Meier - Small Structures, 2024 - Wiley Online Library
Two convergent approaches for synthesizing a new class of nucleoside diphosphate
prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides …
prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides …