The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …

A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …

Recent human decedent model studies, and compassionate xenograft use have explored
the promise of porcine organs for human transplantation. To proceed to human studies, a …

The clinical applicability of porcine xenotransplantation—a long-investigated alternative to
the scarce availability of human organs for patients with organ failure—is limited by …

The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …

We report orthotopic (life‐supporting) survival of genetically engineered porcine cardiac
xenografts (with six gene modifications) for almost 9 months in baboon recipients. This work …

The shortage of available organs remains the greatest barrier to expanding access to
transplant. Despite advances in genetic editing and immunosuppression, survival in …

Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa
(TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is …

Background Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated
antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells …

Glycans–simple or complex carbohydrates–play key roles as recognition determinants and
modulators of numerous physiological and pathological processes. Thus, many …