Glycosylation in health and disease
C Reily, TJ Stewart, MB Renfrow, J Novak - Nature Reviews Nephrology, 2019 - nature.com
The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …
Progress in xenotransplantation: overcoming immune barriers
M Sykes, DH Sachs - Nature Reviews Nephrology, 2022 - nature.com
A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …
Consequently, thousands of patients die every year while waiting for a transplant. Progress …
Design and testing of a humanized porcine donor for xenotransplantation
RP Anand, JV Layer, D Heja, T Hirose, G Lassiter… - Nature, 2023 - nature.com
Recent human decedent model studies, and compassionate xenograft use have explored
the promise of porcine organs for human transplantation. To proceed to human studies, a …
the promise of porcine organs for human transplantation. To proceed to human studies, a …
Extensive germline genome engineering in pigs
The clinical applicability of porcine xenotransplantation—a long-investigated alternative to
the scarce availability of human organs for patients with organ failure—is limited by …
the scarce availability of human organs for patients with organ failure—is limited by …
Xenotransplantation: current status in preclinical research
T Lu, B Yang, R Wang, C Qin - Frontiers in immunology, 2020 - frontiersin.org
The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …
Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months
We report orthotopic (life‐supporting) survival of genetically engineered porcine cardiac
xenografts (with six gene modifications) for almost 9 months in baboon recipients. This work …
xenografts (with six gene modifications) for almost 9 months in baboon recipients. This work …
[HTML][HTML] Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion
SC Kim, DV Mathews, CP Breeden… - American Journal of …, 2019 - Elsevier
The shortage of available organs remains the greatest barrier to expanding access to
transplant. Despite advances in genetic editing and immunosuppression, survival in …
transplant. Despite advances in genetic editing and immunosuppression, survival in …
Kidney transplantation from triple‐knockout pigs expressing multiple human proteins in cynomolgus macaques
D Ma, T Hirose, G Lassiter, H Sasaki… - American Journal of …, 2022 - Wiley Online Library
Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa
(TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is …
(TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is …
Humoral reactivity of renal transplant-waitlisted patients to cells from GGTA1/CMAH/B4GalNT2, and SLA class I knockout pigs
Background Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated
antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells …
antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells …
The challenges of glycan recognition with natural and artificial receptors
S Tommasone, F Allabush, YK Tagger… - Chemical Society …, 2019 - pubs.rsc.org
Glycans–simple or complex carbohydrates–play key roles as recognition determinants and
modulators of numerous physiological and pathological processes. Thus, many …
modulators of numerous physiological and pathological processes. Thus, many …