Disregarding the widely used division of skull base into anterior and lateral, since the skull
base should be conceived as a single anatomic structure, it was to our convenience to group …

Two major issues about local treatment remain unresolved: when to complement surgery
with radiation therapy, and how best to deliver high doses of radiation therapy to the tumor …

Background Adequate surgery still remains the only curative treatment of chordoma.
Interesting clinical data on advanced disease with molecularly targeted therapies were …

Brain plasticity is the potential of the nervous system to reshape itself during ontogeny,
learning or following injuries. The first part of this article reviews the pathophysiological …

Object Chordomas and chondrosarcomas of the skull base are aggressive and locally
destructive tumors with a high tendency for local progression despite treatment. The authors …

Object The purpose of this study was to evaluate radiosurgical outcomes in skull base
chordomas and chondrosarcomas, and to determine which tumors are appropriate for …

Chordomas are rare malignant tumors that are postulated to arise from remnants of the
notochord. Currently, the interaction between chordomas and the host immune system is …

Purpose Chordomas are locally destructive tumors with high rates of recurrence, and
therapeutic strategies remain controversial. This study analyzed long-term outcomes for …

Chondrosarcoma (CSA) of the skull base (SB) is an uncommon, slowly growing, neoplasm
comprising approximately 0.1% of all intracranial tumors and 6% of SB lesions. Even though …

Chordomas and chondrosarcomas occur rarely in the skull base and have been often
considered commonly with respect to the management. The aim of this study was to …