Lysosomes are the primary degradative compartment within cells and there have been
significant advances over the past decade toward understanding how lysosome …

Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

Purpose: This was a study prospectively evaluating intratumoral T-cell responses to
autologous somatic mutated neoepitopes expressed by human metastatic ovarian cancers …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

INTRODUCTION In response to aging, senescence plays a major role in the onset of various
degenerative diseases, including the slow development of cataracts, a clouding of the eye …

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We
showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic …

Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have
emerged as regulators of key sub-cellular processes such as membrane transport …

It remains a great challenge to achieve sufficient cancer classification accuracy with the
entire set of genes, due to the high dimensions, small sample size, and big noise of gene …

In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …