The teleology of sex differences has been argued since at least as early as Aristotle's
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …

Nuclear receptors represent a large family of ligand-activated transcription factors which
sense the physiological environment and make long-term adaptations by mediating …

One feature of hypertension is a microbial imbalance with increased intestinal permeability.
In this study, we examined whether an alteration in the microbiota affects blood pressure …

Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology.
The ubiquitin-proteasome system (UPS) represents a highly regulated quality control …

The study of rare monogenic forms of hypertension has led to the elucidation of important
physiological pathways controlling blood pressure. Mutations in several genes cause …

Aims Salt-sensitive (SS) hypertension is accompanied by impaired vasodilation in the
systemic and renal circulation. However, the causal relationship between vascular …

The National Heart, Lung, and Blood Institute convened a multidisciplinary working group of
hypertension researchers on December 6 to 7, 2018, in Bethesda, MD, to share current …

Arterial stiffness predicts cardiovascular disease and all-cause mortality, but its treatment
remains challenging. Mice treated with angiotensin II (Ang II) develop hypertension, arterial …

Systemic arterial hypertension is a public health problem associated with an increased risk
of cardiovascular disease. Matrix metalloproteinases (MMP) are endopeptidases that …

We previously showed that impaired vasodilation in systemic and renal vessels contributes
to salt-sensitive hypertension in a mouse model of impaired PPARγ (peroxisome proliferator …