Multimorbidity and quality of life: systematic literature review and meta-analysis

TT Makovski, S Schmitz, MP Zeegers, S Stranges… - Ageing research …, 2019 - Elsevier
Multimorbidity is typically defined as the co-existence of two or more chronic diseases within
an individual. Its prevalence is highest among the elderly, with poor quality of life (QoL) …

Multimorbidity and depression: a systematic review and meta-analysis

JR Read, L Sharpe, M Modini, BF Dear - Journal of affective disorders, 2017 - Elsevier
Background Multimorbidity, the presence of two or more chronic conditions, is increasingly
common and complicates the assessment and management of depression. The aim was to …

Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals …

YY Tan, V Papez, WH Chang, SH Mueller… - The Lancet Healthy …, 2022 - thelancet.com
Summary Background Randomised controlled trials (RCTs) inform prescription guidelines,
but stringent eligibility criteria exclude individuals with vulnerable characteristics, which we …

Smoking, drinking, diet and physical activity—modifiable lifestyle risk factors and their associations with age to first chronic disease

R Ng, R Sutradhar, Z Yao, WP Wodchis… - International journal …, 2020 - academic.oup.com
Background This study examined the incidence of a person's first diagnosis of a selected
chronic disease, and the relationships between modifiable lifestyle risk factors and age to …

Association between multimorbidity and hospitalization in older adults: systematic review and meta-analysis

LP Rodrigues, AT de Oliveira Rezende… - Age and …, 2022 - academic.oup.com
Background Multimorbidity is defined as the presence of multiple chronic conditions in the
same individual. Multimorbidity is more prevalent in older adults and can lead to several …

[HTML][HTML] Benefits and harms of exercise therapy in people with multimorbidity: a systematic review and meta-analysis of randomised controlled trials

A Bricca, LK Harris, M Jäger, SM Smith, CB Juhl… - Ageing research …, 2020 - Elsevier
Objectives To investigate the benefits and harms of exercise therapy on physical and
psychosocial health in people with multimorbidity. Design Systematic review of randomised …

Inequalities in incident and prevalent multimorbidity in England, 2004–19: a population-based, descriptive study

A Head, K Fleming, C Kypridemos… - The Lancet Healthy …, 2021 - thelancet.com
Background The increasing burden of multimorbidity and its socioeconomic gradient poses
unique challenges to the provision and structure of health care. We aimed to describe …

Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study

YMJ Goërtz, AMJ Braamse, MA Spruit, DJA Janssen… - Scientific Reports, 2021 - nature.com
To evaluate the prevalence of severe and chronic fatigue in subjects with and without
chronic disease;(2) to assess to which extent multi-morbidity contributes to severe and …

Identifying and understanding the health and social care needs of older adults with multiple chronic conditions and their caregivers: a scoping review

KS McGilton, S Vellani, L Yeung, J Chishtie… - BMC geriatrics, 2018 - Springer
Background As the population is aging, the number of persons living with multiple chronic
conditions (MCC) is expected to increase. This review seeks to answer two research …

Multimorbidity trends in United States adults, 1988–2014

DE King, J Xiang, CS Pilkerton - The Journal of the American …, 2018 - Am Board Family Med
Importance: The simultaneous presence of multiple conditions in one patient (multi-
morbidity) is a key challenge facing primary care. Objective: The purpose of this study was to …