The pathogenesis of the antiphospholipid syndrome
B Giannakopoulos, SA Krilis - New England Journal of Medicine, 2013 - Mass Medical Soc
The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies.
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …
Oxidative stress in the pathology and treatment of systemic lupus erythematosus
A Perl - Nature Reviews Rheumatology, 2013 - nature.com
Oxidative stress is increased in systemic lupus erythematosus (SLE), and it contributes to
immune system dysregulation, abnormal activation and processing of cell-death signals …
immune system dysregulation, abnormal activation and processing of cell-death signals …
Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases?
PL Meroni, MO Borghi, C Grossi… - Nature Reviews …, 2018 - nature.com
Recurrent thrombosis and miscarriages are the main clinical manifestations of
antiphospholipid syndrome (APS). Although most patients display both clinical signs, some …
antiphospholipid syndrome (APS). Although most patients display both clinical signs, some …
Pathogenesis and management of antiphospholipid syndrome
DRJ Arachchillage, M Laffan - British journal of haematology, 2017 - Wiley Online Library
Antiphospholipid antibodies are a heterogeneous group of autoantibodies that have clear
associations with thrombosis and pregnancy morbidity, and which together constitute the …
associations with thrombosis and pregnancy morbidity, and which together constitute the …
mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency
Transaldolase deficiency predisposes to chronic liver disease progressing from cirrhosis to
hepatocellular carcinoma (HCC). Transition from cirrhosis to hepatocarcinogenesis depends …
hepatocellular carcinoma (HCC). Transition from cirrhosis to hepatocarcinogenesis depends …
Diagnosis and management of the antiphospholipid syndrome
S Chaturvedi, KR McCrae - Blood reviews, 2017 - Elsevier
Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy
complications in the presence of persistent antiphospholipid antibodies (APLA). Laboratory …
complications in the presence of persistent antiphospholipid antibodies (APLA). Laboratory …
Antiphospholipid syndrome and the neurologist: from pathogenesis to therapy
T Fleetwood, R Cantello, C Comi - Frontiers in neurology, 2018 - frontiersin.org
Antiphospholipid syndrome (APS) is an autoimmune antibody-mediated condition
characterized by thrombotic events and/or pregnancy morbidity in association with persistent …
characterized by thrombotic events and/or pregnancy morbidity in association with persistent …
The significance of autoantibodies against β2-glycoprotein I
PG de Groot, RT Urbanus - Blood, The Journal of the American …, 2012 - ashpublications.org
The antiphospholipid syndrome (APS) is defined by the persistent presence of
antiphospholipid antibodies in patients with a history of thrombosis and/or pregnancy …
antiphospholipid antibodies in patients with a history of thrombosis and/or pregnancy …
Autoantigenesis: the evolution of protein modifications in autoimmune disease
HA Doyle, MJ Mamula - Current opinion in immunology, 2012 - Elsevier
Protein targets in autoimmune disease vary in location, originating within cells as in system
lupus erythematosus (SLE), or found on cell surfaces or in extracellular spaces. The term …
lupus erythematosus (SLE), or found on cell surfaces or in extracellular spaces. The term …
[PDF][PDF] Mitochondrial dysfunction in the liver and antiphospholipid antibody production precede disease onset and respond to rapamycin in lupus‐prone mice
Objective Antiphospholipid antibodies (aPL) constitute a diagnostic criterion of systemic
lupus erythematosus (SLE), and aPL have been functionally linked to liver disease in …
lupus erythematosus (SLE), and aPL have been functionally linked to liver disease in …