Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …

Correct expression of the genetic code at translation is directly correlated with tRNA identity.
This survey describes the molecular signals in tRNAs that trigger specific aminoacylations …

As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …

A list of currently identified gene products of Escherichia coli is given, together with a
bibliography that provides pointers to the literature on each gene product. A scheme to …

Entire reconstitution of tRNAs for active protein production in a cell-free system brings
flexibility into the genetic code engineering. It can also contribute to the field of cell-free …

The biosynthesis of histidine in Escherichia coli and Salmonella typhimurium has been an
important model system for the study of relationships between the flow of intermediates …

Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …

The peptide bond formation with the amino acid proline (Pro) on the ribosome is slow,
resulting in translational stalling when several Pro have to be incorporated into the peptide …

THE correct attachment of amino acids to their corresponding (cognate) transfer RNA
catalysed by aminoacyl-tRNA synthetases is a key factor in ensuring the fidelity of protein …

The aminoacyl‐tRNA synthetases are an ancient group of enzymes that catalyze the
covalent attachment of an amino acid to its cognate transfer RNA. The question of specificity …