Organ-on-a-chip technology for the study of the female reproductive system

RE Young, DD Huh - Advanced drug delivery reviews, 2021 - Elsevier
Over the past decade, organs-on-a-chip and microphysiological systems have emerged as a
disruptive in vitro technology for biopharmaceutical applications. By enabling new …

Co-adaptation of physical attributes of the mammalian female reproductive tract and sperm to facilitate fertilization

CK Tung, SS Suarez - Cells, 2021 - mdpi.com
The functions of the female reproductive tract not only encompass sperm migration, storage,
and fertilization, but also support the transport and development of the fertilized egg through …

High DNA integrity sperm selection using surface acoustic waves

J Gai, R Nosrati, A Neild - Lab on a Chip, 2020 - pubs.rsc.org
Male infertility is a global reproductive issue, several clinical approaches have been
developed to tackle it, but their effectiveness is limited by the labour-intensive and time …

FertDish: microfluidic sperm selection-in-a-dish for intracytoplasmic sperm injection

S Xiao, J Riordon, M Simchi, A Lagunov, T Hannam… - Lab on a Chip, 2021 - pubs.rsc.org
The selection of high quality sperm is critical for intracytoplasmic sperm injection (ICSI), a
prevalent assisted reproduction technology. However, standard selection methods are time …

[HTML][HTML] Emerging microfluidic technologies for sperm sorting

J Huang, H Chen, N Li, Y Zhao - Engineered Regeneration, 2023 - Elsevier
Sorting high-quality sperm with intact DNA, normal morphology, and active motility is crucial
for clinically assisted reproductive technology, which influences the success of treatment …

A fully integrated biomimetic microfluidic device for evaluation of sperm response to thermotaxis and chemotaxis

Y Yan, B Zhang, Q Fu, J Wu, R Liu - Lab on a Chip, 2021 - pubs.rsc.org
In recent decades, humans have faced greater challenges in reproduction. Assisted
reproductive technology is the most prominent approach for addressing this problem …

Biological benefits of collective swimming of sperm in a viscoelastic fluid

S Phuyal, SS Suarez, CK Tung - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Collective swimming is evident in the sperm of several mammalian species. In bull (Bos
taurus) sperm, high viscoelasticity of the surrounding fluid induces the sperm to form …

Recent microfluidic innovations for sperm sorting

M Khodamoradi, S Rafizadeh Tafti… - Chemosensors, 2021 - mdpi.com
Sperm selection is a clinical need for guided fertilization in men with low-quality semen. In
this regard, microfluidics can provide an enabling platform for the precise manipulation and …

Selection of high-quality sperm with thousands of parallel channels

M Simchi, J Riordon, JB You, Y Wang, S Xiao… - Lab on a Chip, 2021 - pubs.rsc.org
Sperm selection is essential for successful fertilization and embryo development. Current
clinical sperm selection methods are labor-intensive and lack the selectivity required to …

Microfluidics: The future of sperm selection in assisted reproduction

AR Jahangiri, N Ziarati, E Dadkhah, MN Bucak… - …, 2024 - Wiley Online Library
Background Obtaining functional sperm cells is the first step to treat infertility. With the ever‐
increasing trend in male infertility, clinicians require access to effective solutions that are …