The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …

Background Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several
epithelial cancers and is closely associated with poor prognosis. However, the role of …

T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …

Wnt/β-catenin signaling plays a key role in the pathogenesis of colon and other cancers;
emerging evidence indicates that oncogenic β-catenin regulates several biological …

Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology.
From the earliest observation that Wnt overexpression could lead to malignant …

The evolutionarily conserved Wnt signaling pathway plays essential roles during embryonic
development and tissue homeostasis. Notably, comprehensive genetic studies in …

The Wnt family of secreted ligands act through many receptors to stimulate distinct
intracellular signalling pathways in embryonic development, in adults and in disease …

Prior studies have identified recurrent oncogenic mutations in colorectal adenocarcinoma
and have surveyed exons of protein-coding genes for mutations in 11 affected individuals …

Known genetic loci explain only a small proportion of the familial relative risk of colorectal
cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with …