Since its initial involvement in numerous neurodegenerative pathologies in 2006, either as a
principal actor or as a cofactor, new pathologies implicating transactive response (TAR) …

Abstract RNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing
all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on …

Initiation of timely and sufficient zygotic genome activation (ZGA) is crucial for the beginning
of life, yet our knowledge of transcription factors (TFs) contributing to ZGA remains limited …

Oocytes are among the longest-lived cells in the body and need to preserve their cytoplasm
to support proper embryonic development. Protein aggregation is a major threat for …

Zygotic genome activation (ZGA), the first transcription event following fertilization, kickstarts
the embryonic program that takes over the control of early development from the maternal …

Major zygotic genome activation (ZGA) occurs at the late 2‐cell stage and involves the
activation of thousands of genes, supporting early embryonic development. The reasons …

Transcription decodes protein-coding genes and interprets regulatory information
embedded in the genome by generating RNA. In eukaryotes, gene transcription is coupled …