Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry
Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …
synaptic transmission, are widely distributed throughout the central nervous system, and …
Life extension factor klotho enhances cognition
Aging is the primary risk factor for cognitive decline, an emerging health threat to aging
societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive …
societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive …
[HTML][HTML] Peripheral elevation of a klotho fragment enhances brain function and resilience in young, aging, and α-synuclein transgenic mice
Cognitive dysfunction and decreased mobility from aging and neurodegenerative
conditions, such as Parkinson and Alzheimer diseases, are major biomedical challenges in …
conditions, such as Parkinson and Alzheimer diseases, are major biomedical challenges in …
GluN2B subunit-containing NMDA receptor antagonists prevent Aβ-mediated synaptic plasticity disruption in vivo
NW Hu, I Klyubin, R Anwyl… - Proceedings of the …, 2009 - National Acad Sciences
Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine
provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the …
provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the …
NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear
Synaptic plasticity mediated by NMDA glutamate receptors is thought to be a primary
mechanism underlying the formation of new memories. Activation of GluN2A NMDA receptor …
mechanism underlying the formation of new memories. Activation of GluN2A NMDA receptor …
Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research
MR Dauvermann, G Lee… - British journal of …, 2017 - Wiley Online Library
The pharmacological modulation of glutamatergic neurotransmission to improve cognitive
function has been a focus of intensive research, particularly in relation to the cognitive …
function has been a focus of intensive research, particularly in relation to the cognitive …
Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression
G Rammes, LK Starker, R Haseneder, J Berkmann… - …, 2009 - Elsevier
Postoperative cognitive dysfunction (POCD) is a decline in cognitive performance after a
surgery performed under anaesthesia. The exact roles of surgery and/or anaesthesia for …
surgery performed under anaesthesia. The exact roles of surgery and/or anaesthesia for …
The role of P2X7 receptors in a rodent PCP-induced schizophrenia model
B Koványi, C Csölle, S Calovi, A Hanuska, E Kató… - Scientific Reports, 2016 - nature.com
Abstract P2X7 receptors (P2X7Rs) are ligand-gated ion channels sensitive to extracellular
ATP. Here we examined for the first time the role of P2X7R in an animal model of …
ATP. Here we examined for the first time the role of P2X7R in an animal model of …
Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats
X Wang, Y Shan, Z Tang, L Gao… - Drug Design, Development …, 2018 - Taylor & Francis
Background Considerable evidences support the finding that the anesthesia reagent
isoflurane increases neuronal cell death in young rats. Recent studies have shown that …
isoflurane increases neuronal cell death in young rats. Recent studies have shown that …