The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …

Muscle specific signaling has been shown to originate from myofilaments and their
associated cellular structures, including the sarcomeres, costameres or the cardiac …

Striated muscle responds to mechanical overload by rapidly up-regulating the expression of
the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to …

It was well documented that macro/trace elements were associated with the
neurodevelopment. We aimed to investigate the relationship between copper (Cu)/zinc …

The cross-bridge theory predicts that muscle force is determined by muscle length and the
velocity of active muscle length changes. However, before the formulation of the cross …

The active isometric force produced by muscles varies with muscle length in accordance
with the force–length relationship. Compared with isometric contractions at the same final …

Since its belated discovery, our understanding of the giant protein titin has grown
exponentially from its humble beginning as a sarcomeric scaffold to recent recognition of its …

The sliding filament–swinging cross bridge theory of skeletal muscle contraction provides a
reasonable description of muscle properties during isometric contractions at or near …

The N2A segment of titin is a main signaling hub in the sarcomeric I-band that recruits
various signaling factors and processing enzymes. It has also been proposed to play a role …

Titin, the largest single chain protein known so far, has long been known to play a critical
role in passive muscle function but recent studies have highlighted titin's role in active …