Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co‐exist. The one airway
model proposes that disease mechanisms occurring in the upper airway may mirror lower …

Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

Asthma is an increasingly common disease that remains poorly understood and difficult to
manage. This disease is characterized by airway hyperreactivity (AHR, defined by …

The endothelial cells play a crucial role in the progression of angiogenesis, which causes
cell re-modulation, proliferation, adhesion, migration, invasion and survival. Angiogenic …

Rationale: Increased thickness of the airway smooth muscle (ASM) layer in asthma may
result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix …

METHODS The left or right lungs of cadavers coming to Coroner's autopsy within the
metropolitan area of Perth, Western Australia, were obtained if the cause of death was …

This study was designed to determine the potential importance of airway wall thickening in
the pathogenesis of the excess airways narrowing of asthma. The airways in postmortem …

Normal lung development follows a series of orchestrated events. Premature birth interrupts
normal in utero lung development, which results in significant alterations in lung function …

Asthma and chronic obstructive pulmonary disease (COPD) are characterised by airflow
obstruction, airway remodelling (measurable structural change) and inflammation. The …

Airway-wall remodeling leading to thickening of the bronchial wall in asthma has been
invoked to account for airflow obstruction and increased bronchial reactivity to provocative …