Nitric oxide and immune responses in cancer: Searching for new therapeutic strategies

A Sahebnasagh, F Saghafi, S Negintaji… - Current medicinal …, 2022 - ingentaconnect.com
In recent years, there has been an increasing interest in understanding the mysterious
functions of nitric oxide (NO) and how this pleiotropic signaling molecule contributes to …

Regulation of transcription factors by reactive oxygen species and nitric oxide in vascular physiology and pathology

S Kohlgrüber, A Upadhye, N Dyballa-Rukes… - Antioxidants & redox …, 2017 - liebertpub.com
Significance: Cardiovascular diseases are the main cause of death worldwide and pose an
immense economical burden. In most cases, the underlying problem is vascular occlusion …

The aryl hydrocarbon receptor promotes aging phenotypes across species

A Eckers, S Jakob, C Heiss, T Haarmann-Stemmann… - Scientific reports, 2016 - nature.com
The ubiquitously expressed aryl hydrocarbon receptor (AhR) induces drug metabolizing
enzymes as well as regulators of cell growth, differentiation and apoptosis. Certain AhR …

MiR‐484 suppressed proliferation, migration, invasion and induced apoptosis of gastric cancer via targeting CCL‐18

J Liu, SM Li - International Journal of Experimental Pathology, 2020 - Wiley Online Library
Gastric cancer is a common and high‐incidence malignant gastro‐intestinal cancer that
seriously threatens human life. Evidence suggests that microRNAs (miRNAs) play an …

Role of telomerase in the cardiovascular system

M Zurek, J Altschmied, S Kohlgrüber, N Ale-Agha… - Genes, 2016 - mdpi.com
Aging is one major risk factor for the incidence of cardiovascular diseases and the
development of atherosclerosis. One important enzyme known to be involved in aging …

Rare deleterious variants in GRHL3 are associated with human spina bifida

P Lemay, P De Marco, A Emond… - Human …, 2017 - Wiley Online Library
Neural tube defects, including spina bifida, are among the most common birth defects
caused by failure of neural tube closure during development. They have a complex etiology …

MicroRNA-23a-3p influences the molecular mechanism of gastric cancer cells via CCL22/PI3K/Akt axis

Z Jiang, M Su, H Chen, L Wu, X Yu, Z Liu - Bioengineered, 2021 - Taylor & Francis
ABSTRACT A great many microRNAs (miRNAs) have been reported to play different roles in
human cancers, including gastric cancer (GC). However, the specific character of miR-23a …

[HTML][HTML] The Adhesion GPCR ADGRL2/LPHN2 Can Protect Against Cellular and Organismal Dysfunction

P Jakobs, A Rafflenbeul, WB Post, N Ale-Agha… - Cells, 2024 - mdpi.com
The most common trigger of sepsis and septic shock is bacterial lipopolysaccharide (LPS).
Endothelial cells are among the first to encounter LPS directly. Generally, their function is …

The significance of elevated plasma expression of microRNA 106b~ 25 clusters in gastric cancer

F Li, Y Guo, J Liu, R Zhang - PLoS One, 2017 - journals.plos.org
Objective Concentrating on oncogenic role and increased plasma expression of microRNA
(miR) 106b~ 25 clusters (involving miR 106b, miR 93 and miR 25), we evaluated …

[HTML][HTML] Alternative splicing and start sites: Lessons from the Grainyhead-like family

LB Miles, S Dworkin, C Darido - Developmental biology, 2017 - Elsevier
The two main mechanisms that expand the proteomic output of eukaryotic genes are
alternative splicing and alternative translation initiation signals. Despite being essential to …