Hyperacusis is a debilitating loudness intolerance disorder that can evoke annoyance, fear
and aural facial pain. Although the auditory system seems to be the “central” player …

Significance: The stria vascularis, located in the inner ear, consists of three layers, one of
which is the blood–labyrinth barrier (BLB). It is formed by endothelial cells, sealed together …

Age-related hearing loss (ARHL) is an irreversible, progressive neurodegenerative disorder
and is presently untreatable. Previous studies using animal models have suggested …

Noise exposure affects the organ of Corti and the lateral wall of the cochlea, including the
stria vascularis and spiral ligament. Although the inner ear vasculature and spiral ligament …

Sensory hair cells are prone to apoptosis caused by various drugs including aminoglycoside
antibiotics. In mammals, this vulnerability results in permanent hearing loss because lost …

Noise-induced hearing loss (NIHL) is associated with both acute and chronic noise
exposure. The application of steroid hormones is the first-line treatment for NIHL. However, a …

Sensorineural hearing loss (SNHL) represents a significant clinical challenge,
predominantly attributed to oxidative stress-related mechanisms. In this work, we report an …

Acoustic trauma induces an inflammatory response in the cochlea, resulting in debilitating
hearing function. Clinically, amelioration of inflammation substantially prevents noise …

Cisplatin (CDDP) is an extensively used chemotherapeutic agent but has a high incidence
of severe ototoxicity. Although a few molecules have entered clinical trials, none have been …

Herein, dexamethasone (DEX) nanocrystalline suspension (NS)-embedded hydrogel (NS-
G) was constructed using a hydroxypropyl methylcellulose (HPMC) polymer to enhance …