The mucosal immune system is the largest component of the entire immune system, having
evolved to provide protection at the main sites of infectious threat: the mucosae. As SARS …

Since its first discovery in December 2019, the global coronavirus disease 2019 (COVID-19)
pandemic caused by the novel coronavirus (SARS-CoV-2) has been posing a serious threat …

The central nervous system has historically been viewed as an immune-privileged site, but
recent data have shown that the meninges—the membranes that surround the brain and …

COVID-19 antibodies on trial | Nature Biotechnology Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …

Tripartite motif containing-21 (TRIM21) is a cytosolic ubiquitin ligase and antibody receptor
that provides a last line of defense against invading viruses. It does so by acting as a sensor …

The global coronavirus disease 2019 (COVID-19) pandemic has had significant economic
and social impacts on billions of people worldwide since severe acute respiratory syndrome …

Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high
levels of protective antibodies. Antibodies targeting the middle capsid protein VP6 are …

Mucosal immunity plays a significant role in host defense against viruses in the respiratory
tract. Because the upper respiratory airway is a primary site of SARS-CoV-2 entry …

The innate antiviral response is integral in protecting the host against virus infection. Many
proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin …