The multiple links between actin and mitochondria

TS Fung, R Chakrabarti, HN Higgs - Nature Reviews Molecular Cell …, 2023 - nature.com
Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …

Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer

CS Palmer, AJ Anderson, D Stojanovski - FEBS letters, 2021 - Wiley Online Library
The majority of proteins localised to mitochondria are encoded by the nuclear genome, with
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …

Subtiligase-catalyzed peptide ligation

AM Weeks, JA Wells - Chemical reviews, 2019 - ACS Publications
Subtiligase-catalyzed peptide ligation is a powerful approach for site-specific protein
bioconjugation, synthesis and semisynthesis of proteins and peptides, and chemoproteomic …

A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis

E Peker, K Weiss, J Song, C Zarges, S Gerlich… - Journal of Cell …, 2023 - rupress.org
Mitochondria critically rely on protein import and its tight regulation. Here, we found that the
complex I assembly factor NDUFAF8 follows a two-step import pathway linking IMS and …

Protein translocation into the intermembrane space and matrix of mitochondria: mechanisms and driving forces

S Backes, JM Herrmann - Frontiers in molecular biosciences, 2017 - frontiersin.org
Mitochondria contain two aqueous subcompartments, the matrix and the intermembrane
space (IMS). The matrix is enclosed by both the inner and outer mitochondrial membranes …

Sensitive determination of proteolytic proteoforms in limited microscale proteome samples

SSH Weng, F Demir, EK Ergin, S Dirnberger… - Molecular & Cellular …, 2019 - ASBMB
Protein N termini unambiguously identify truncated, alternatively translated or modified
proteoforms with distinct functions and reveal perturbations in disease. Selective enrichment …

[HTML][HTML] Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome

MF Mabanglo, KS Wong, MM Barghash, E Leung… - Structure, 2023 - cell.com
The mitochondrial ClpP protease is responsible for mitochondrial protein quality control
through specific degradation of proteins involved in several metabolic processes. ClpP …

Life and death of proteins after protease cleavage: protein degradation by the N‐end rule pathway

N Dissmeyer, S Rivas, E Graciet - New Phytologist, 2018 - Wiley Online Library
Contents Summary 929 I. Introduction: conservation and diversity of N‐end rule pathways
929 II. Defensive functions of the N‐end rule pathway in plants 930 III. Proteases and …

Direct identification of proteolytic cleavages on living cells using a glycan-tethered peptide ligase

K Schaefer, I Lui, JR Byrnes, E Kang, J Zhou… - ACS central …, 2022 - ACS Publications
Proteolytic cleavage of cell surface proteins triggers critical processes including cell–cell
interactions, receptor activation, and shedding of signaling proteins. Consequently …

Current advances in gene therapy of mitochondrial diseases

VO Soldatov, MV Kubekina, MY Skorkina… - Journal of translational …, 2022 - Springer
Mitochondrial diseases (MD) are a heterogeneous group of multisystem disorders involving
metabolic errors. MD are characterized by extremely heterogeneous symptoms, ranging …