Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

The term 'tripartite synapse'refers to a concept in synaptic physiology based on the
demonstration of the existence of bidirectional communication between astrocytes and …

Glia are as numerous in the brain as neurons and widely known to serve supportive roles
such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and …

Astrocytes are housekeepers of the central nervous system (CNS) and are important for
CNS development, homeostasis and defence. They communicate with neurones and other …

In this perspective, I review recent evidence that glial cells are critical participants in every
major aspect of brain development, function, and disease. Far more active than once …

Lysosomes were once considered the end point of endocytosis, simply used for
macromolecule degradation. They are now recognized to be dynamic organelles, able to …

The past decade has seen an explosion of research on roles of neuron-astrocyte
interactions in the control of brain function. We highlight recent studies performed on the …

In the past 20 years, an extra layer of information processing, in addition to that provided by
neurons, has been proposed for the CNS. Neuronally evoked increases of the intracellular …

Several neurodegenerative disorders involve impaired neurotransmission, and
glutamatergic neurotransmission sets a prototypical example. Glutamate is a predominant …