▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …

Despite significant progress in the past 20 years, graft-versus-host disease (GVHD) remains
a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell …

The detection of primitive hematopoietic cells based on repopulation of immune-deficient
mice is a powerful tool to characterize the human stem-cell compartment. Here, we identify a …

Studies on pluripotent hematopoietic stem cells (HSCs) have been hindered by lack of a
positive marker, comparable to the CD34 marker of hematopoietic progenitor cells (HPCs) …

We used a mouse transplantation model to address the recent controversy about CD34
expression by hematopoietic stem cells. Cells from Ly-5.1 C57BL/6 mice were used as …

While stem cell cryopreservation methods have been optimized using dimethylsulfoxide
(DMSO), the established techniques are not optimal when applied to unfertilized human …

The proliferative responsiveness of granulocyte colony-stimulating factor (G-CSF)–mobilized
blood was studied in uni-directional mixed leukocyte cultures. Unfractionated mononuclear …

Allogeneic transplantation of cytokine-mobilized peripheral blood stem cells (PBSCs) is now
being increasingly performed, but safety considerations for hematologically normal PBSC …

The most common cause of post-transplant mortality in patients with hematological
malignancy is relapse, followed by GvHD, infections, organ toxicity and second malignancy …

After primary recovery of platelet counts after transplantation, there can be a late persistent
decline called secondary failure of platelet recovery (SFPR), which may occur although the …