Axons are guided along specific pathways by attractive and repulsive cues in the
extracellular environment. Genetic and biochemical studies have led to the identification of …

Eph receptors constitute the largest family of tyrosine kinase receptors and, together with
their plasma-membrane-bound ephrin ligands, have many important functions during …

The nematode Caenorhabditis elegans was chosen as a model genetic organism because
its attributes, chiefly its hermaphroditic lifestyle and rapid generation time, make it suitable …

Wound healing involves a coordinated series of tissue movements that bears a striking
resemblance to various embryonic morphogenetic episodes. There are several ways in …

The control of cell movement during development is essential for forming and stabilizing the
spatial organization of tissues and cell types. During initial steps of tissue patterning, distinct …

Eph receptor tyrosine kinases and ephrins have key roles in regulation of the migration and
adhesion of cells required to form and stabilize patterns of cell organization during …

Craniofrontonasal syndrome (CFNS) is an X-linked developmental disorder that shows
paradoxically greater severity in heterozygous females than in hemizygous males. Females …

Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

Members of the Eph family of receptor tyrosine kinases control many aspects of cellular
interactions during development, including axon guidance. Here, we demonstrate that …

Cell-to-cell communication during development and plasticity is controlled to a large extent
by signaling events downstream of receptor tyrosine kinases (RTKs). Most RTKs bind …