Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

The light-driven steps in the biogenesis and repair of the inorganic core comprising the O2-
evolving center of oxygenic photosynthesis (photosystem II water-oxidation complex, PSII …

Natural photosynthetic protein complexes capture sunlight to power the energetic catalysis
that supports life on Earth. Yet these natural protein structures carry an evolutionary legacy …

The primary processes of photosynthesis lead to transformation of solar radiation into
electrochemical Gibbs energy-the driving force for life on Earth. These intricate and …

The ability to harvest light to drive chemical reactions and gain energy provided microbes
access to high energy electron donors which fueled primary productivity, biogeochemical …

Quinones play important roles in biological electron transfer reactions in almost all
organisms, with specific roles in many physiological processes and chemotherapy …

Acid-sensing ion channel (ASIC)-1a, the major ASIC subunit with Ca2+ permeability, is
highly expressed in the neurons of CNS. Activation of these channels with resultant …

Due to the great abundance of genomes and protein structures that today span a broad
diversity of organisms, now more than ever before, it is possible to reconstruct the molecular …

Distance and relative orientation of functional groups within protein domains and their
changes during chemical reactions determine the efficiency of biological processes. In this …

One of the key biochemical developments during the evolution of life was the invention of
the oxygen-evolving complex (OEC) of photosystem II, responsible for catalyzing the …