Exploratory genomic analysis of high-grade neuroendocrine neoplasms across diverse primary sites

TY Sun, L Zhao, P Van Hummelen… - Endocrine-related …, 2022 - erc.bioscientifica.com
High-grade (grade 3) neuroendocrine neoplasms (G3 NENs) have poor survival outcomes.
From a clinical standpoint, G3 NENs are usually grouped regardless of primary site and …

[HTML][HTML] Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer

Y Lee, SH Dho, J Lee, JH Hwang, M Kim… - … & molecular medicine, 2022 - nature.com
Despite numerous observations regarding the relationship between DNA methylation
changes and cancer progression, only a few genes have been verified as diagnostic …

Evolutionary patterns of chromosomal instability and mismatch repair deficiency in proximal and distal colorectal cancer

MM Golas, B Gunawan, M Cakir, S Cameron… - Colorectal …, 2022 - Wiley Online Library
Abstract Aim Colorectal carcinomas (CRCs) progress through heterogeneous pathways.
The aim of this study was to analyse whether or not the cytogenetic evolution of CRC is …

[HTML][HTML] Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

GW Shin, SU Greer, E Hopmans, SM Grimes, HJ Lee… - Genome medicine, 2021 - Springer
We developed a sensitive sequencing approach that simultaneously profiles microsatellite
instability, chromosomal instability, and subclonal structure in cancer. We assessed diverse …

[HTML][HTML] Clinical relevance of BCOR internal tandem duplication and TP53 aberration in clear cell sarcoma of the kidney

M Zhang, X Yao, X Guan, C Jia, R Zhang, H Wang… - Human Pathology, 2023 - Elsevier
Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal
malignancy, characterized by BCOR internal tandem duplication (ITD), YWHAE …

The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Gastric Cancer

AF Almeda, SM Grimes, HJ Lee, S Greer… - … Biomarkers & Prevention, 2022 - AACR
Background: Gastric cancer is a leading cause of cancer morbidity and mortality. Developing
information systems which integrate clinical and genomic data may accelerate discoveries to …

The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Stomach Malignancies

AF Almeda, S Grimes, HJ Lee, SU Greer, GW Shin… - medRxiv, 2022 - medrxiv.org
Background Gastric cancer (GC) is a leading cause of global cancer morbidity and mortality.
Developing information systems which integrate clinical and genomic data may accelerate …

Análisis de alteraciones del número de copias y variantes de un único nucleótido en la evolución de adenoma a adenocarcinoma colorrectal mediante secuenciación …

M Lozano García - 2021 - openaccess.uoc.edu
Durante la progresión de adenoma (AD) a adenocarcinoma (ADK) en el cáncer colorrectal
(CCR), las células adquieren alteraciones genómicas, tanto en el número de copia (CNA) …

Method for diagnosing colorectal cancer by detecting intragenic methylation

LK Kim, Y Lee, J Lee, SH Dho - US Patent App. 17/810,823, 2023 - Google Patents
2022-10-28 Assigned to INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI
UNIVERSITY reassignment INDUSTRY-ACADEMIC COOPERATION FOUNDATION …

Method for determining if a tumor has a mutation in a microsatellite

G Shin, HP Ji - US Patent App. 17/634,223, 2022 - Google Patents
A method for determining if a tumor has a mutation in a microsatellite is provided. In some
embodiments, the method may comprise:(a) isolating genomic DNA from a tumor sample …