Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with
limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (> …

ABSTRACT SHOC2 is a prototypical leucine-rich repeat protein that promotes downstream
receptor tyrosine kinase (RTK)/RAS signaling and plays important roles in several cellular …

The mechanisms of Myc-driven liver tumorigenesis are inadequately understood. Herein we
show that Myc-driven hepatocellular carcinoma (HCC) is dramatically aggravated in mice …

The combination of BRAF and MEK inhibitors (BRAFi/MEKi) has shown promising response
rates in treating BRAF-mutant melanoma by inhibiting ERK activation. However, treatment …

Src homology-2 domain-containing phosphatase 2 (SHP2) is a ubiquitously expressed
phosphatase that is vital for skeletal development and maintenance of chondrocytes …

This study evaluates the efficacy of combining targeted therapies with MET or SHP2
inhibitors to overcome MET-mediated resistance in different NSCLC subtypes. A prevalence …

Targeting KRAS downstream signaling remains an important therapeutic approach in
pancreatic cancer. We used primary pancreatic ductal epithelial cells and mouse models …

Mutations in the receptor tyrosine kinases (RTKs) FLT3 and KIT are frequent and associated
with poor outcomes in acute myeloid leukemia (AML). Although selective FLT3 inhibitors …

This study evaluates the efficacy of combining targeted therapies with MET or SHP2
inhibitors to overcome MET-mediated resistance in different NSCLC subtypes. A prevalence …