An increase in the omega-6/omega-3 fatty acid ratio increases the risk for obesity

AP Simopoulos - Nutrients, 2016 - mdpi.com
In the past three decades, total fat and saturated fat intake as a percentage of total calories
has continuously decreased in Western diets, while the intake of omega-6 fatty acid …

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire

LFC Castro, DR Tocher, O Monroig - Progress in lipid research, 2016 - Elsevier
Long-chain polyunsaturated fatty acids (LC-PUFA) are major components of complex lipid
molecules and are also involved in numerous critical biological processes. Studies …

Position of the academy of nutrition and dietetics: dietary fatty acids for healthy adults

G Vannice, H Rasmussen - Journal of the Academy of Nutrition and …, 2014 - Elsevier
It is the position of the Academy of Nutrition and Dietetics (the Academy) that dietary fat for
the healthy adult population should provide 20% to 35% of energy, with an increased …

Comprehensive profiling of plasma fatty acid concentrations in young healthy Canadian adults

SA Abdelmagid, SE Clarke, DE Nielsen, A Badawi… - PloS one, 2015 - journals.plos.org
Circulating fatty acids (FA) are associated with a multitude of chronic diseases. However, a
major gap in establishing such relationships is the lack of accepted fatty acid reference …

Gamma-linolenic acid, dihommo-gamma linolenic, eicosanoids and inflammatory processes

S Sergeant, E Rahbar, FH Chilton - European journal of pharmacology, 2016 - Elsevier
Abstract Gamma-linolenic acid (GLA, 18: 3n-6) is an omega-6 (n-6), 18 carbon (18C-)
polyunsaturated fatty acid (PUFA) found in human milk and several botanical seed oils and …

Genomics in personalized nutrition: can you “eat for your genes”?

VA Mullins, W Bresette, L Johnstone, B Hallmark… - Nutrients, 2020 - mdpi.com
Genome-wide single nucleotide polymorphism (SNP) data are now quickly and
inexpensively acquired, raising the prospect of creating personalized dietary …

Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials

GH Johnson, K Fritsche - Journal of the Academy of Nutrition and Dietetics, 2012 - Elsevier
The majority of evidence suggests that n-6 polyunsaturated fatty acids, including linoleic
acid (LA), reduce the risk of cardiovascular disease as reflected by current dietary …

Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids

A Ameur, S Enroth, Å Johansson, G Zaboli, W Igl… - The American Journal of …, 2012 - cell.com
Omega-3 and omega-6 long-chain polyunsaturated fatty acids (LC-PUFAs) are essential for
the development and function of the human brain. They can be obtained directly from food …

Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease

F Tosi, F Sartori, P Guarini, O Olivieri… - Oxidative stress and …, 2014 - Springer
Polyunsaturated fatty acids (PUFA) play pleiotropic and crucial roles in biological systems.
Both blood and tissue levels of PUFA are influenced not only by diet, but to a large extent …

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium

W Guan, BT Steffen, RN Lemaitre, JHY Wu… - Circulation …, 2014 - Am Heart Assoc
Background—Omega6 (n6) polyunsaturated fatty acids (PUFAs) and their metabolites are
involved in cell signaling, inflammation, clot formation, and other crucial biological …