Early evaluation of treatment response and prediction of disease evolution are key issues in
the management of people with multiple sclerosis (MS). In the past 20 years, MRI has …

Multiple sclerosis (MS) is an inflammatory disorder of the CNS that affects both the brain and
the spinal cord. MRI studies in MS focus more often on the brain than on the spinal cord …

ABSTRACT BACKGROUND AND PURPOSE Spinal cord atrophy (SCA) is an important
emerging outcome measure in multiple sclerosis (MS); however, there is limited consensus …

The spinal cord is frequently affected in multiple sclerosis (MS), causing motor, sensory and
autonomic dysfunction. A number of pathological abnormalities, including demyelination …

Magnetic resonance imaging (MRI) is the most powerful tool for the early (differential)
diagnosis of multiple sclerosis (MS) and has been part of the International Panel criteria …

Thalamic atrophy is known to be one of the most important predictors for clinical dysfunction
in multiple sclerosis (MS). As the thalamus is highly connected to many cortical areas, this …

Introduction Multiple sclerosis (MS) is characterised by the accumulation of permanent
neurological disability secondary to irreversible tissue loss (neurodegeneration) in the brain …

Objective To assess whether cervical spinal cord atrophy heralds the onset of progressive
MS. Methods We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 …

Despite extensive research into the pathophysiology of multiple sclerosis (MS) and recent
developments in potent disease-modifying therapies (DMTs), two-thirds of relapsing …

Conversion to secondary progressive (SP) course is the decisive factor for long-term
prognosis in relapsing multiple sclerosis (MS), generally considered the clinical equivalent …