Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication

W Wang, KN Klein, K Proesmans, H Yang, C Marchal… - Molecular cell, 2021 - cell.com
The heterogeneous nature of eukaryotic replication kinetics and the low efficiency of
individual initiation sites make mapping the location and timing of replication initiation in …

G-Quadruplexes and DNA replication origins

MN Prioleau - DNA Replication: From Old Principles to New …, 2017 - Springer
DNA replication ensures the accurate duplication of the genome at each cell cycle. During S
phase, tens of thousands of replication origins throughout the vertebrate genome are …

Cell cycle stage-specific transcriptional activation of cyclins mediated by HAT2-dependent H4K10 acetylation of promoters in Leishmania donovani

U Chandra, A Yadav, D Kumar, S Saha - PLoS Pathogens, 2017 - journals.plos.org
Chromatin modifications affect several processes. In investigating the Leishmania donovani
histone acetyltransferase HAT2, using in vitro biochemical assays and HAT2-heterozygous …

Integrating high-throughput analysis to create an atlas of replication origins in Trypanosoma cruzi in the context of genome structure and variability

MO Vitarelli, TA Franco, DS Pires, ARJ Lima, VL Viala… - Mbio, 2024 - Am Soc Microbiol
Trypanosoma cruzi is the etiologic agent of the most prevalent human parasitic disease in
Latin America, Chagas disease. Its genome is rich in multigenic families that code for …

Life cycle stage-specific accessibility of Leishmania donovani chromatin at transcription start regions

J Grünebast, S Lorenzen, J Zummack, J Clos - Msystems, 2021 - Am Soc Microbiol
Leishmania donovani is a parasitic protist that causes the lethal Kala-azar fever in India and
East Africa. Gene expression in Leishmania is regulated by gene copy number variation and …

Genome-wide quantification of polycistronic transcription in Leishmania major

J Grünebast, S Lorenzen, J Clos - mBio, 2024 - journals.asm.org
Leishmania major is a human-pathogenic, obligate parasite and the etiological agent of the
most prevalent, cutaneous form of leishmaniasis, which is an important neglected, tropical …