Biology of the BKPyV: an update

F Helle, E Brochot, L Handala, E Martin, S Castelain… - Viruses, 2017 - mdpi.com
The BK virus (BKPyV) is a member of the Polyomaviridae family first isolated in 1971. BKPyV
causes frequent infections during childhood and establishes persistent infections with …

Human polyomaviruses: the battle of large and small tumor antigens

CF Baez, R Brandão Varella… - Virology: research …, 2017 - journals.sagepub.com
About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the
polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To …

An elusive target: inhibitors of JC polyomavirus infection and their development as therapeutics for the treatment of progressive multifocal leukoencephalopathy

J Kaiserman, BA O'Hara, SA Haley… - International Journal of …, 2023 - mdpi.com
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease caused
by infection with JC Polyomavirus (JCPyV). Despite the identification of the disease and …

BK polyomavirus activates the DNA damage response to prolong S phase

JL Justice, JM Needham, SR Thompson - Journal of Virology, 2019 - Am Soc Microbiol
ABSTRACT BK polyomavirus (PyV) is a major source of kidney failure in transplant
recipients. The standard treatment for patients with lytic BKPyV infection is to reduce …

[HTML][HTML] Polyomavirus Large T antigens: Unraveling a Complex Interactome

MR Googins, P An, CH Gauthier, JM Pipas - Tumour Virus Research, 2024 - Elsevier
All members of the polyomavirus family encode a large T antigen (LT) protein that plays
essential roles in viral DNA replication, regulation of viral gene expression, and the …

Understanding polyomavirus CNS disease–a perspective from mouse models

KN Ayers, SN Carey, AE Lukacher - The FEBS journal, 2022 - Wiley Online Library
JC polyomavirus (JCPyV), a ubiquitous human pathogen, causes several devastating brain
diseases in immune‐compromised individuals. The most notable of these JCPyV …

JCPyV VP1 mutations in progressive multifocal leukoencephalopathy: altering tropism or mediating immune evasion?

MD Lauver, AE Lukacher - Viruses, 2020 - mdpi.com
Polyomaviruses are ubiquitous human pathogens that cause lifelong, asymptomatic
infections in healthy individuals. Although these viruses are restrained by an intact immune …

Stimulation of BK virus DNA replication by NFI family transcription factors

B Liang, I Tikhanovich, HP Nasheuer… - Journal of virology, 2012 - Am Soc Microbiol
ABSTRACT BK polyomavirus (BKV) establishes persistent, low-level, and asymptomatic
infections in most humans and causes polyomavirus-associated nephropathy (PVAN) and …

Inhibition of human BK polyomavirus replication by small noncoding RNAs

I Tikhanovich, B Liang, C Seoighe, WR Folk… - Journal of …, 2011 - Am Soc Microbiol
Small noncoding RNAs regulate a variety of cellular processes, including genomic
imprinting, chromatin remodeling, replication, transcription, and translation. Here, we report …

Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination

C Herate, C Vigne, CA Guenzel, M Lambele… - Retrovirology, 2016 - Springer
Background Through incorporation into virus particles, the HIV-1 Vpr protein participates in
the early steps of the virus life cycle by influencing the reverse transcription process. We …