Integrated analysis of antimicrobial, antioxidant, and phytochemical properties of Cinnamomum verum: A comprehensive In vitro and In silico study

SH Al-Mijalli, HN Mrabti, N El Hachlafi… - Biochemical Systematics …, 2023 - Elsevier
This study aims to investigate the chemical composition, antibacterial, antifungal, and
antioxidant properties of C. verum essential oil (EO). The antimicrobial potential of C. verum …

[HTML][HTML] Analysis of SYK gene as a prognostic biomarker and suggested potential bioactive phytochemicals as an alternative therapeutic option for colorectal cancer …

P Biswas, D Dey, A Rahman, MA Islam… - Journal of Personalized …, 2021 - mdpi.com
Background: SYK gene regulates the expression of SYK kinase (Spleen tyrosine kinase), an
important non-receptor protein-tyrosine kinase for immunological receptor-mediated …

Synthesis, DFT calculations, biological investigation, molecular docking studies of β-lactam derivatives

A Mermer, H Bayrak, S Alyar, M Alagumuthu - Journal of Molecular …, 2020 - Elsevier
In this study β-lactam derivatives which include 1, 3, 4-thiadiazole and 1, 3, 4-oxadiazole
structure (8a, b) have been achieved by cyclocondensation reaction. The synthesized …

Combined Bioinformatics and Combinatorial Chemistry Tools to Locate Drug‐Able Anti‐TB Phytochemicals: A Cost‐Effective Platform for Natural Product‐Based Drug …

SS Swain, T Hussain - Chemistry & Biodiversity, 2022 - Wiley Online Library
Based on extensive experimental studies, a huge number of phytochemicals showed
potential activity against tuberculosis (TB) at a lower minimum inhibitory concentration (MIC) …

Synthesis and discovery of pyrazolo-pyridine analogs as inflammation medications through pro-and anti-inflammatory cytokine and COX-2 inhibition assessments

JD Bilavendran, A Manikandan, P Thangarasu… - Bioorganic …, 2020 - Elsevier
This article briefs about the efforts taken to synthesis, characterize and develop (E)-5-methyl-
2-phenyl-3-(thiophen-2-yl)-7-(thiophen-2-ylmethylene)-3, 3a, 4, 5, 6, 7-hexahydro-2H …

Synthesis and Evaluation of Biological Activities for a Novel 1, 2, 3, 4-Tetrahydroisoquinoline Conjugate with Dipeptide Derivatives: Insights from Molecular Docking …

SR Tivari, SV Kokate, JL Belmonte-Vázquez… - ACS …, 2023 - ACS Publications
Peptide synthesis has opened new frontiers in the quest for bioactive molecules with
limitless biological applications. This study presents the synthesis of a series of novel …

Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition …

B Bindu, S Vijayalakshmi, A Manikandan - European Journal of Medicinal …, 2020 - Elsevier
A family of 12 triazolo-pyridazine-6-yl-substituted piperazines (5a-l) was synthesized and
evaluated for their Dipeptidyl peptidase-4 (DPP-4) inhibition potentials in order to develop …

Cu-mediated synthesis of differentially substituted diazepines as AChE inhibitors; validation through molecular docking and Lipinski's filter to develop novel anti …

N Sudhapriya, A Manikandan, MR Kumar… - Bioorganic & Medicinal …, 2019 - Elsevier
A highly efficient Cu-mediated route for the synthesis of fused [1, 2, 3] triazolo [1, 4]
diazepines has been developed by azidation-cyclization of 2-bromo-N-propargylamines in a …

Norfloxacin derivatives as DNA gyrase and urease inhibitors: synthesis, biological evaluation and molecular docking

B Awan, MA Khan, I Ahmad, A Masood… - Future Medicinal …, 2023 - Taylor & Francis
Background: DNA gyrase and urease enzymes are important targets for the treatment of
gastroenteritis, appendicitis, tuberculosis, urinary tract infections and Crohn's disease …

Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity …

P Thangarasu, A Manikandan, S Thamaraiselvi - Bioorganic Chemistry, 2019 - Elsevier
As the global need for drugs getting increases, the necessity of novel and effective drugs are
the need of the day. Pyrazoles are one of the active molecules in novel drug discovery. The …