A steady increase of product titers and the corresponding change in impurity composition
represent a challenge for development and optimization of antibody production processes …

Whey proteins, which possess the highest nutritional quality of all food proteins, are an
optimal source of functional food ingredients. Enzymatic hydrolysis of whey proteins …

The purification of biopharmaceuticals is commonly considered the bottleneck of the
manufacturing process. Increasing product diversity, along with growing regulatory and …

Quality by Design (QbD) is gaining industry acceptance as an approach towards
development and commercialization of biotechnology therapeutic products that are …

The downstream processing of virus particles for vaccination or gene therapy is becoming a
critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to …

While packed bed chromatography, known as conventional chromatography, has been
serving the biopharmaceutical industry for decades as the bioseparation method of choice …

Innovative biologics, including cell therapeutics, virus-like particles, exosomes, recombinant
proteins, and peptides, seem likely to substitute monoclonal antibodies as the main …

Continuous bioprocessing is significantly changing the biological drugs (or biologics)
manufacturing landscape by potentially improving product quality, process stability, and …

The thermodynamic modeling of protein adsorption on mixed-mode adsorbents
functionalized with ligands carrying both hydrophobic and electrostatic groups was …

Dramatic improvements in cell culture titers, product quality constraints, new regulatory
directives, and the emergence of biosimilars have necessitated the development of more …