Cholesterol and components of the cholesterol biosynthetic pathway have fundamental
roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as …

The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and
domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for …

▪ Abstract Recent studies showing that detergent-resistant membrane fragments can be
isolated from cells suggest that biological membranes are not always in a liquid-crystalline …

Membrane rafts are dynamic, small (10–200 nm) domains enriched with cholesterol and
sphingolipids that compartmentalize cellular processes. Rafts participate in roles essential to …

Alphaviruses are small, spherical, enveloped, positive-sense ssRNA viruses responsible for
a considerable number of human and animal diseases. Alphavirus members include …

Arboviruses (or arthropod-borne viruses), represent a threat for the new century. The 2005–
2006 year unprecedented epidemics of chikungunya virus (CHIKV) in the French Reunion …

ABSTRACT A number of recent studies have demonstrated the significance of detergent-
insoluble, glycolipid-enriched membrane domains or lipid rafts, especially in regard to …

As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries
for completion of their replication cycle. The recent discovery of the heterogeneous …

Abstract Structure–function studies have defined two classes of viral membrane-fusion
proteins that have radically different architectures but adopt a similar overall'hairpin' …

Previous studies have indicated that human immunodeficiency virus (HIV) is enclosed with a
lipid envelope similar in composition to cell plasma membranes and to other viruses …