Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …

Nuclear receptors (NRs) are ligand-activated transcription factors sharing a common
evolutionary history and having similar sequence features at the protein level. Selective …

Pregnane X receptor is a ligand-activated nuclear receptor (NR) that mainly controls
inducible expression of xenobiotics handling genes including biotransformation enzymes …

Chemotherapy is one of the three most common treatment modalities for cancer. However,
its efficacy is limited by multidrug resistant cancer cells. Drug metabolizing enzymes (DMEs) …

Humans are chronically exposed to multiple exogenous substances, including
environmental pollutants, drugs and dietary components. Many of these compounds are …

Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-
disrupting chemicals (EDCs). A vast body of literature links exposure to these chemicals with …

The consensus view is that vertebrate-type steroids are present in mollusks and perform
hormonal roles which are similar to those that they play in vertebrates. Although vertebrate …

The steroid and xenobiotic receptor (SXR)(also known as pregnane X receptor or PXR) is a
nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary …

Steroid hormones regulate many physiological processes in vertebrates, nematodes and
arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand …