Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …

Abstract Biological Pathway Exchange (BioPAX) is a standard language to represent
biological pathways at the molecular and cellular level and to facilitate the exchange of …

High-throughput studies of biological systems are rapidly accumulating a wealth of'omics'-
scale data. Visualization is a key aspect of both the analysis and understanding of these …

Background The increasing availability and diversity of omics data in the post-genomic era
offers new perspectives in most areas of biomedical research. Graph-based biological …

In past years, comprehensive representations of cell signalling pathways have been
developed by manual curation from literature, which requires huge effort and would benefit …

Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and
cellular conditions. The mechanistic details of how a cell chooses among these cell fates are …

Protein interactions play an important role in the discovery of protein functions and pathways
in biological processes. This is especially true in case of the diseases caused by the loss of …

Many important problems in cell biology require the consideration of dense nonlinear
interactions between functional modules. The requirement of computer simulation for the …

Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of
metastases during tumour progression. Here, to investigate its role in intestinal cancer, we …

Cancer is a complex and heterogeneous disease that exhibits high levels of robustness
against various therapeutic interventions. It is a constellation of diverse and evolving …