Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …

A wealth of evidence indicates a strong link between type 2 diabetes (T2D) and
neurodegenerative diseases such as Alzheimer's disease (AD). Although the precise …

Defects in insulin production and signaling are suspected to share a key role in diabetes
and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the …

The gestational state is a period of particular vulnerability to diseases that affect maternal
and fetal health. Stress during gestation may represent a powerful influence on maternal …

In the past few decades, the prevalence of obesity and type 2 diabetes mellitus (T2DM), as
well as older individuals at risk for Alzheimer's disease (AD), has increased. While the …

Genome-wide association studies (GWASs) provide an unprecedented opportunity to
examine, on a large scale, the association of common genetic variants with complex …

Significance: Epidemiological studies indicate that metabolic disorders are associated with
an increased risk for Alzheimer's disease (AD). Metabolic remodeling occurs in the central …

This study assessed the extent to which high fat diet (HFD)-induced β-amyloid accumulation
and cognitive decline in APP/PSEN1 mice are reversible through control of fat intake. Ten …

Insulin is a key hormone regulating metabolism. Insulin binding to cell surface insulin
receptors engages many signaling intermediates operating in parallel and in series to …