Oscillation quenching constitutes a fundamental emergent phenomenon in systems of
coupled nonlinear oscillators. Its importance for various natural and man-made systems …

Parkinson's disease arises from genetic and possibly neurotoxic causes that produce
massive cell death of the neuromelanin-containing dopaminergic neurons of the substantia …

Multicompartment emulation is an essential step to enhance the biological realism of
neuromorphic systems and to further understand the computational power of neurons. In this …

The fundamental building block of every nervous system is the single neuron.
Understanding how these exquisitely structured elements operate is an integral part of the …

We used a preparation of acutely dissociated neurons to quantify the ionic currents driving
the spontaneous firing of substantia nigra pars compacta neurons, isolated from transgenic …

Dopamine is involved in motivation, memory, and reward processing. However, it is not clear
whether the activity of dopamine neurons is related or not to vigilance states. Using unit …

Dopamine (DA) midbrain neurons project to several striatal and cortical target areas and are
essentially involved in a puzzling variety of important brain functions such as action …

At least 70% of the afferents to substantia nigra dopaminergic neurons are GABAergic. The
vast majority of these arise from the neostriatum, the external globus pallidus and the …

Although the roles of dopaminergic signaling in learning and behavior are well established,
it is not fully understood how the activity of dopaminergic neurons is dynamically regulated …

Summary Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disorder caused by
a polyglutamine expansion within the Ataxin-2 (Atxn2) protein. Purkinje cells (PC) of the …