Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …

The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

Background Recent gains in reducing the global burden of malaria are threatened by the
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that …

Background Emergence of artemisinin resistance in southeast Asia poses a serious threat to
the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has …

The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the
global malaria burden. We genetically modified the Plasmodium falciparum K13 locus using …

In Tanzania, chloroquine was replaced by sulphadoxine-pyrimethamine (SP) as a first-line
for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP …

Plasmodium falciparum resistance to artemisinins, the most potent and fastest acting anti-
malarials, threatens malaria elimination strategies. Artemisinin resistance is due to mutation …

Background. The emergence of artemisinin resistance in the malaria parasite Plasmodium
falciparum poses a major threat to the control and elimination of malaria. Certain point …

Abstract Background The emergence of Plasmodium falciparum resistance to artemisinin
and its derivatives, manifested as delayed parasite clearance following the treatment, has …

Partial artemisinin resistance, defined in patients as a delayed parasite clearance following
artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta …