Dynamic interactomics by cross-linking mass spectrometry: mapping the daily cell life in postgenomic era

L Santorelli, M Caterino, M Costanzo - OMICS: A Journal of …, 2022 - liebertpub.com
The majority of processes that occur in daily cell life are modulated by hundreds to
thousands of dynamic protein–protein interactions (PPI). The resulting protein complexes …

Ynamide Coupling Reagent for the Chemical Cross-Linking of Proteins in Live Cells

S Li, C Zhu, Q Zhao, ZM Zhang, P Sun… - ACS Chemical Biology, 2023 - ACS Publications
Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) is a
powerful method for the study of protein structure and protein–protein interactions (PPIs) …

Shape shifting: The multiple conformational substates of the PTEN N‐terminal PIP2‐binding domain

JE Dawson, IN Smith, W Martin, K Khan… - Protein …, 2022 - Wiley Online Library
Abstract The Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) is a
chief regulator of a variety of cellular processes including cell proliferation, migration …

Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex

K Khan, B Long, V Gogonea… - Proceedings of the …, 2022 - National Acad Sciences
Amino acid ligation to cognate transfer RNAs (tRNAs) is catalyzed by aminoacyl-tRNA
synthetases (aaRSs)—essential interpreters of the genetic code during translation …