Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, and can be
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …

Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the
hypothesis that lactate could function as an oncometabolite by evaluating whether lactate …

Unlike adult cancers that frequently result from the accumulation in time of mutational “hits”
often linked to lifestyle, childhood cancers are emerging as diseases of dysregulated …

Endothelial and skeletal muscle lineages arise from common embryonic progenitors.
Despite their shared developmental origin, adult endothelial cells (ECs) and muscle stem …

Endothelial and skeletal muscle lineages arise from common embryonic progenitors.
Despite their shared developmental origin, adult endothelial cells (ECs) and muscle stem …

Soft tissue sarcoma (STS) comprise a large group of mesenchymal malignant tumors with
heterogeneous cellular morphology, proliferative index, genetic lesions and, more …

Rhabdomyosarcoma (RMS) is a malignant soft tissue tumor of skeletal muscle origin. The
head and neck, urinary tract, and extremities are the common sites of origin. Embryonal …

Rhabdomyosarkome (RMS) sind die häufigsten pädiatrischen Weichteilsarkome. Trotz
eines multimodalen Behandlungsansatzes leiden 20% aller pädiatrischen Sarkompatient …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in early childhood.
Despite recent advances in the treatment regimes of rhabdomyosarcoma, the 5-year survival …

Pediatric solid tumors often present with a non-permissive cold immune cell
microenvironment that contributes to immunotherapy resistance. Being a major component …