Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …

Parasitic diseases have an enormous health, social and economic impact and are a
particular problem in tropical regions of the world. Diseases caused by protozoa and …

ChEMBL is an open large-scale bioactivity database (https://www. ebi. ac. uk/chembl),
previously described in the 2012 Nucleic Acids Research Database Issue. Since then, a …

Malaria elimination has recently been reinstated as a global health priority but current
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …

This digest covers some of the most relevant progress in malaria drug discovery published
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …

Drug repurposing is a strategy consisting of finding new indications for already known
marketed drugs used in various clinical settings or highly characterized compounds despite …

Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load
and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for …

Better antibiotics capable of killing multi-drug-resistant Mycobacterium tuberculosis are
urgently needed. Despite extensive drug discovery efforts, only a few promising candidates …

There is a growing need for new antibiotics. Compounds that target the proton motive force
(PMF), uncouplers, represent one possible class of compounds that might be developed …

Malaria is a devastating disease caused by Plasmodium parasites, resulting in
approximately 435000 deaths in 2018. The impact of malaria is compounded by the …