The rapid proliferation of cancer cells combined with deficient vessels cause regions of
nutrient and O2 deprivation in solid tumors. Some cancer cells can adapt to these extreme …

The past decades have shown significant advancements in the development of solid tumor
treatment. For instance, implementation of nanosystems for drug delivery has led to a …

The bioluminescence signal generated by the luciferase-luciferin interaction, exploited for
real-time and continuous monitoring of numerous biochemical processes in living cells and …

Bioluminescence imaging is a highly sensitive technique commonly used for various in vivo
applications. Recent efforts to expand the utility of this modality have led to the development …

Abstract Chimeric Antigen Receptor T cell (CAR-T) therapy has emerged as a transformative
therapeutic strategy for hematological malignancies. However, its efficacy in treating solid …

Bioluminescence (BL) is an amazing natural phenomenon whose visible light is produced
by living organisms. BL phenomenon is quite pervasive and has been observed in 17 phyla …

Significant progress has been made in tumor immunotherapy that uses the human immune
response to kill and remove tumor cells. However, overreactive immune response could …

Bioluminescence imaging (BLI) is useful to monitor cell movement and gene expression in
live animals. However, D-luciferin has a short wavelength (560 nm) which is absorbed by …

Bioluminescence reactions are widely applied in optical in vivo imaging in the life science
and medical fields. Such reactions produce light upon the oxidation of a luciferin (substrate) …

Tumor vasculature proliferates rapidly, generally lacks pericyte coverage, and is uniquely
fragile making it an attractive therapeutic target. A subset of small-molecule tubulin binding …