The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

The lung is the primary site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2)-induced immunopathology whereby the virus enters the host cells by binding to …

About 2,000 patients now await a donor lung in the United States. Worldwide, 50 million
individuals are living with end-stage lung disease. Creation of a bioartificial lung requires …

Summary Two populations of Nkx2-1+ progenitors in the developing foregut endoderm give
rise to the entire postnatal lung and thyroid epithelium, but little is known about these cells …

It has been postulated that during human fetal development, all cells of the lung epithelium
derive from embryonic, endodermal, NK2 homeobox 1–expressing (NKX2-1+) precursor …

Deriving lung progenitors from patient-specific pluripotent cells is a key step in producing
differentiated lung epithelium for disease modeling and transplantation. By mimicking the …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …

Animal models of cystic fibrosis (CF) are powerful tools that enable the study of the
mechanisms and complexities of human disease. Murine models have several intrinsic …

Lung diseases remain a significant and devastating cause of morbidity and mortality
worldwide. In contrast to many other major diseases, lung diseases notably chronic …