Almost 2 decades after linking LRRK2 to Parkinson's disease, a vibrant research field has
developed around the study of this gene and its protein product. Recent studies have begun …

Oxidative stress reflects an imbalance between the overproduction and incorporation of free
radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free …

Falls are a major determinant of poor quality of life, immobilization, and reduced life
expectancy in people affected by Parkinson's disease (PD) and in older adults more …

Abstract Purpose of Review The sense of smell is today one of the focuses of interest in
aging and neurodegenerative disease research. In several neurodegenerative diseases …

Background The traditional evaluation of gait in the laboratory during structured testing has
provided important insights, but is limited by its “snapshot” character and observation in an …

Diverse but complementary methodologies are required to uncover the complex
determinants and pathophysiology of freezing of gait. To develop future therapeutic …

Background Postural instability and gait disability threaten the independence and well-being
of people with Parkinson's disease and increase the risk of falls and fall-related injuries …

Parkinson's disease (PD) is a heterogeneous progressive neurodegenerative disorder,
which typically affects older adults; it is predicted that by 2030 about 3% of the world …

The heterogeneity of Parkinson's disease (PD) has been recognized since its description by
James Parkinson over 200 years ago. The complexity of motor and non-motor PD …

Background Reduced arm swing is a well‐known clinical feature of Parkinson's disease
(PD), often observed early in the course of the disease. We hypothesized that subtle …