Epidemiological evidence conclusively demonstrates that calcium burden is a significant
predictor of cardiovascular morbidity and mortality; however, the underlying mechanisms …

Heritability of bone mineral density (BMD) varies across skeletal sites, reflecting different
relative contributions of genetic and environmental influences. To quantify the degree to …

Increased cardiovascular morbidity and mortality in chronic kidney disease (CKD)
represents an emerging major health problem. Indeed, disturbances in mineral and bone …

Extracellular vesicles (EVs), spherical bilayered proteolipids, behave as paracrine effectors
since they are released from cells to deliver signals to other cells. They control a diverse …

Osteoporosis is a common skeletal disorder characterized by low bone mass leading to
increased bone fragility and fracture susceptibility. In this study, we have identified pathways …

Background Ectopic vascular calcifications represent a major clinical problem associated
with cardiovascular disease and mortality. However, the mechanisms underlying …

The human neuron-specific gene, GPM6B (Glycoprotein membrane 6B), is considered a key
gene in neural cell functionality. This gene contains an exceptionally long and strictly …

Age-related skeletal degeneration in patients with osteoporosis is characterized by
decreased bone mass and occurs concomitant with an increase in bone marrow adipocytes …

Both the dental pulp and the apical papilla represent a promising source of mesenchymal
stem cells for regenerative endodontic protocols. The aim of this study was to outline …

Background Human periodontal ligament stem cells (hPDLSCs) are ideal seed cells for
periodontal regeneration. A greater understanding of the dynamic protein profiles during …